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placebo-controlled
Geraghty RJ
InChi: InChI=1S/C25H27N3O2/c1-24(2
InChiKey: YAYLZJMYAWCSFK-MAHXAKIKSA-N
BS-181 dihydrochloride enzamine Hydrochloride placebo-controlledBS 181 dihydrochloride is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY 30237). BS 181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880 nM, 3000 nM and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS 181 dihydrochloride inhibits a panel of cancer cells growth (IC50=11. 5 M 37. 3 M) and induces cell apoptosis. BS 181 dihydrochloride has the potential for the research of cancer therapy. Product information
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