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Kaddoumi A
InChi: InChI=1S/C39H62N6O6S/c1-11-25(4)33(44(8)37(48)32(24(2)3)43-38(49)39(6
Dragnev KH
p110β and p110γ only at much higher concentrations
PF-3084014 - CAS# 1290543-63-3 Catalog No.:M10295-10 Kaddoumi ANirogacestat, also known as PF 03084014, is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. PF 03084014 binds to GS, blocking proteolytic activation of Notch receptors. Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. Nirogacestat enhances docetaxel mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC
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