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Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
but not H3K56ac as revealed by western blot analysis
110(9):3281-90
InChi: InChI=1S/C40H50N8O6
GDC-0449 (Vismodegib) - Hedgehog Antagonist. CAS# 879085-55-9 094 Small Molecules Enhance CRISPR GenomeVismodegib (GDC 0449), CAS No. 879085 55 9, is a potent and specific hedgehog pathway inhibitor with an IC50 of 3 nM. It has been approved by FDA to treat BCC, and also in multiple clinical trials to treat advanced solid tumors. It blocks the activities of the Hedgehog ligand cell surface receptors PTCH and or SMO and suppressing Hedgehog signaling. It prevents multiple ATP binding cassette (ABC) transporters. GDC 0449 also exhibited efficacy in