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4-Octyl Itaconate 18014 SirReal2 can increase tubulin hyperacetylation

SKU: 85806338902

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Description

SirReal2 can increase tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1

An ascending dose PK study in female athymic nude mice shows that the rate of compound release is maximal at 120 mg/kg and all clearance mechanisms can be saturated at 240 mg/kg

InChi: InChI=1S/C15H10N2O2/c1-19-9-2-3-10-11-6-7-16-12-4-5-14(18)17(15(11)12)13(10)8-9/h2-8H

2'-binaphthalen]-4'-yl}-4-methoxybenzene-1-sulfonamide

4-Octyl Itaconate 18014 SirReal2 can increase tubulin hyperacetylation4 Octyl Itaconate is a cell permeable Itaconate derivative. Itaconate is an anti inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Product information CAS Number: 3133 16 2 Molecular Weight: 242. 31 Formula: C13H22O4 Chemical Name: 2 methylidene 4 (octyloxy) 4 oxobutanoic acid Smiles: CCCCCCCCOC(=O)CC(=C)C(O)=O InChiKey: KBASUIDPDITQHT UHFFFAOYSA N InChi: InChI=1S C13H22O4 c1 3 4 5 6 7 8 9 17 12(14)10 11(2)13(15)16 h2

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