Entinostat (MS-275) - HDAC Inhibitor. CAS# 209783-80-2 026 Wild-type zebrafish embryos were treated

Wild-type zebrafish embryos were treated with HLY78 at 80 μM from the three-somite stage until 36 h

PubMed PMID: 22736948

81686-22-8

In vivo it shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model

Entinostat (MS-275) - HDAC Inhibitor. CAS# 209783-80-2 026 Wild-type zebrafish embryos were treatedEntinostat (MS 275), CAS No. 209783 80 2, is a potent and selective HDAC inhibitor. It inhibits HDAC1 and HDAC3 with IC50 of 0. 51 M and 1. 7 M, but not the other HDACs 4, 6, 8, and 10 (IC50 > 100 M). MS 275 induces accumulation of p21WAF1 CIP1 and gelsolin in K562 cell. It was shown to reduce S phase cells and induce G1 phase cells in A2780 cells. MS 275 shows great inhibition to human leukemia and lymphoma cells, decreases expression of cyclin D1