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(Annonaceae)
Smiles: COCCC(CC1(CCCC1)C(=O)NCCCC1C=CC(Cl)=CC=1)C(O)=O
Smiles: OC1=C(NC2=CC=CC=C21)C1=NC2=CC=CC=C2C1=O
vincristine (130-fold) and amsacrine (107-fold) compared to standard drugs alone
Resibufogenin 12145 (Annonaceae)Resibufogenin, a component of huachansu, has been shown to exhibit the anti proliferative effect against cancer cells, and this may be attributed to the degradation of cyclin D1 caused by the activation of GSK 3. IC50 Value: Target: In vitro: The effects of Resibufogenin on the outward delayed rectifier potassium current (IK) and outward transient potassium current (IA) in rat hippocampal neurons was investigated, and it inhibited both IK and IA, at 1