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Bring out your big guns ahead of schedule, or combo off and play limitless goblins with all your extra mana

Then you can +1 him to force only dorks in the zone to block that region this turn, so you can put your beating 5/5 flying Commander into the same zone as some grounded dorks to get past

Twilight's Call could give you a good board position, but everyone else still controls their good creatures

Now, you dont quite win the game on the spot, but if youre able to navigate a game into a position where you are able to protect your Karn and resolve Mycosynth Lattice, your opponent will be completely stripped of their ability to cast anything else, thanks to the one-two punch of Lattice turning all opposing lands in artifacts that now cannot be activated thanks to Karn