PD-166793 2265 1'-pyrano[3

1'-pyrano[3

and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone

14b-icosahydropicene-4

3-dimethyl-2-[(2S)-3-methyl-2-(methylamino)butanamido]butanamido]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl](methoxy)methyl]propanamido]-3-phenylpropanoate

PD-166793 2265 1'-pyrano[3PD 166793 is a potent, selective, orally active and widebroad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP 2, MMP 3 and MMP 13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP 1, 7 and 9 (IC50=6. 0, 7. 2, and 7. 9 M, respectively). PD 166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Product information CAS Number: 199850 67 4 Molecular Weight: 412. 30