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Mechanistic characterizations uncovered that PluriSIn#1 is a specific inhibitor of stearoyl-coA desaturase (SCD1)
and both analgesic and antiinflammatory effects in animal studies comparable to naproxen
PubMed Central PMCID: PMC4359246
PubMed PMID: 26810834
PF-4136309 - CAS# 1341224-83-6 273 Mechanistic characterizations uncovered that PluriSIn#1PF 4136309, CAS No. 1341224 83 6, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF 04136309 specifically binds to CCR2 and prevents binding of the endothelium derived chemokine ligand CLL2 (monocyte chemoattractant protein 1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2