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2017 Mar 21
(2014) AACR San Diego
InChi: InChI=1S/C25H36O5/c1-7-13(2)22(28)30-21-14(3)10-24-11-16(9-17(12-26)20(27)25(21
Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM
BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 2017 Mar 21BO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against
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