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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
342(6161):979-83
It reduces H3K79 dimethylation with a cellular IC50 of 2
is a potent and selective arginine methyltransferase inhibitor
PF-CBP1 - CBP/p300 Bromodomain Inhibitor. CAS# 1962928-21-7 Catalog No.:M60313-10S Important role of the LKB1-AMPKPF CBP1, CAS No. 1962928 21 7, is a potent and selective CBP p300 bromodomain inhibitor (IC50 ~125 nM for CBP and 363 nM for p300). It has >100 fold selectivity for CBP over BRD4, and shows selectivity over a panel of other bromodomains. PF CBP1 reduces LPS induced IL 1, IL 6 and IFN expression in macrophages in vitro. It can also downregulate RGS4 expression in primary cortical neurons in vitro. Product information CAS Number: 1962928 21 7 Molecular