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Formula: C20H15FN4O2S
PubMed PMID: 26231433
which prevents rapid metabolism of trifluiridine
Bioorg Chem
KRN 633 Size:10mg solid Formula: C20H15FN4O2SKRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR 2 (IC50 = 1. 16 nmol L) in human umbilical vein endothelial cells. Selectivity profiling with recombinant tyrosine kinases showed that KRN633 is highly selective for VEGFR 1, 2, and 3. KRN633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats. KRN633
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