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GDC-0152 ridol (Alvocidib) InChiKey: PXXLQQDIFVPNMP-UHFFFAOYSA-N

SKU: 14340430955

4.4
USD95.00 USD120.00

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Description

InChiKey: PXXLQQDIFVPNMP-UHFFFAOYSA-N

Formula: C22H15Br2N3O4

As of December 2013 the drug is not approved for these indications in North America or Europe

It was dosed to diabetic ob/ob mice via oral gavage at 3-30 mg/kg once per day for 2 weeks

GDC-0152 ridol (Alvocidib) InChiKey: PXXLQQDIFVPNMP-UHFFFAOYSA-NGDC 0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC 0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are

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