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ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM
3-dihydro-1H-imidazole-1-carboxylate
8 µM in HN3-rslR cells
DMBX-anabaseine
BIBR 1532 - CAS# 321674-73-1 895 ISRIB is an integrated stressBIBR1532 is a selective telomerase inhibitor. BIBR1132 is highly selective for inhibition of telomerase, resulting in delayed growth arrest of tumor cells. Treatment of cancer cells with BIBR1532 leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag period that is largely dependent on initial telomere length. Product information CAS Number: 321674 73 1 Molecular Weight: 331. 36 Formula:
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