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Advances in clinical cardiology
InChiKey: XLTFNNCXVBYBSX-UHFFFAOYSA-N
which efficiently inhibits ALK2 and ALK3 (IC50=5 nM and 30 nM
Formula: C129H230N36O29S
NB-598 Hydrochloride alafenamide hemifumarate Advances in clinical cardiologyNB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.
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