Pyrimidine-indole hybrid Catalog No.:M34537-C Smiles: [2H]C([2H])(OC1=CC=CC=C1OC)C([2H])(OC(N)=O)C([2H])([2H])O

Smiles: [2H]C([2H])(OC1=CC=CC=C1OC)C([2H])(OC(N)=O)C([2H])([2H])O

26(2):300-306

for 14 days) exhibits dose-dependent inhibition on HT-29 tumor growth in nude mice

12-pentaen-12-yl}oxy)propanamide

Pyrimidine-indole hybrid Catalog No.:M34537-C Smiles: [2H]C([2H])(OC1=CC=CC=C1OC)C([2H])(OC(N)=O)C([2H])([2H])OPyrimidine indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of tubulin. Pyrimidine indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule