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drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies
InChi: InChI=1S/C20H22O5/c1-11-12(2)20(14-5-7-16-18(9-14)24-10-23-16)25-19(11)13-4-6-15(21)17(8-13)22-3/h4-9
AG-490 at 30 μM inhibits not only Epo-induced phosphorylation of wild-type JAK2 but also constitutive phosphorylation of the JAK2 V617F mutant
23)24/h9-12
TG4-155 62175 drawing on tumor incidence dataTG4 155 is a potent, brain permeant and selective EP2 receptor antagonist with a Ki of 9. 9 nM. TG4 155 shows low nanomolar antagonist activity against only EP2 and DP1. TG4 155 has an EP2 Schild KB of 2. 4 nM and displays 550 4750 fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14 fold selectivity against the DP1 receptor. Product information CAS Number: 1164462 05 8 Molecular Weight: 394. 46 Formula: C23H26N2O4 Chemical Name: (2E) N [2