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PubMed Central PMCID: PMC2976054
It can induce proliferation of mouse R7T1 cells with an EC50 ~0
thus causes mitotic spindle defects
1218942-37-0
LY2157299 - TGFβ Inhibitor. CAS# 700874-72-2 size:10mg solid PubMed Central PMCID: PMC2976054LY2157299, CAS No. 700874 72 2, is a novel potent and selective TGF receptor type I and type II (TRI II) inhibitor with IC50 of 86 nM and 2 nM, respectively. LY2157299 could inhibit the TGF induced Smad2 phosphorylation in HUVEC cells, promote VEGF induced HUVEC cell migration, and show dose dependent potentiation of VEGF or bFGF induced cell proliferation. It can also inhibit TGFmediated Smad2 activation and hematopoietic suppression in primary
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