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3-dimethyl-2-oxo-1
I-CBP112 - p300/CBP Bromodomain Inhibitor. CAS# 1640282-31-0 size:2mg solid 3-dimethyl-2-oxo-1I CBP112, CAS No. 1640282 31 0, is a highly potent and selective p300 CBP bromodomain inhibitor (IC50 ~0. 14 0. 17 M for CBP and ~0. 625 M for p300). It binds CBP and p300 bromodomains directly, and has excellent selectivity against the entire bromodomain family in a BLI assay. It accelerated FRAP recovery at 1 M and no significant cytotoxicity up to 50 M in U2OS cells. p300 and CBP are transcriptional co activators that modulate DNA replication, DNA
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