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CN(C)C1C=C[N+](CC2C=CC(=CC=2)OCCOC2C=CC(C[N+]3C=CC(=CC=3)N(C)C)=CC=2)=CC=1
10(12):2267-75
InChi: InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3
Environ Health Perspect
GS967 ibitor VIII CN(C)C1C=C[N+](CC2C=CC(=CC=2)OCCOC2C=CC(C[N+]3C=CC(=CC=3)N(C)C)=CC=2)=CC=1GS967, also known as GS 458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD and DAD mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Selective late INa inhibition with GS967 exerts potent protective effects against ischemia induced depolarization and repolarization abnormalities in both atria and ventricles.
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