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InChi: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H
thereby preventing the conversion of folic acid into tetrahydrofolate
2013 May 2
Kuninaka Y
Tazemetostat trihydrochloride - CAS# 1403255-00-4 NH-C8-NH2 hydrochloride InChi: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13HTazemetostat trihydrochloride (EPZ 6438 trihydrochloride) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat trihydrochloride inhibits the activity of human polycomb repressive complex 2 (PRC2) containing wild type EZH2 with a Ki of 2. 5 nM. Tazemetostat trihydrochloride inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat trihydrochloride inhibits rat EZH2 with an IC50 of 4
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