Pralatrexate - CAS# 146464-95-1 arin Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6

Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6

InChi: InChI=1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7

Formula: C22H25ClN2O8

2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl]carbamoyl}pyrrolidin-1-yl]-3

Pralatrexate - CAS# 146464-95-1 arin Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier 1 (RFC 1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC 1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors;