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After 28 days of Bardoxolone methyl administration
BMS-56224701
CAS Number: 934526-89-3
It allosterically binds (Kd 10-30 nmol/L) to the regulatory Zn(2+) binding domain of HDAC4 that locks the protein in a conformation preventing HDAC4/N-CoR/HDAC3 complex formation
ABT-751 - CAS# 141430-65-1 60163 After 28 days of BardoxoloneABT 751, also known as E7010, CAS No. 141430 65 1, is an orally bioavailable antimitotic sulfonamide. ABT 751 binds to the colchicine binding site on beta tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. Product information CAS Number: 141430 65 1 Molecular Weight: 371. 41 Formula:
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