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Hoflack JC
has pan-PKD inhibitory effects (PKD2 IC50 = 0
but reduces open probability by > 90% with Ki=0
In this study
PT2399 verolimus Hoflack JCPT2399 is a potent and orally available antagonist of HIF 2 that selectively disrupts the heterodimerization of HIF 2 with HIF 1. Product information CAS Number: 1672662 14 4 Molecular Weight: 419. 32 Formula: C17H10F5NO4S Chemical Name: 3 [(1S) 7 (Difluoromethylsulfonyl) 2,2 difluoro 1 hydroxy indan 4 yl]oxy 5 fluoro benzonitrile Smiles: N#CC1=CC(F)=CC(=C1)OC1=CC=C(C2[C@H](O)C(F)(F)CC=21)S(=O)(=O)C(F)F InChiKey: MXUSGDMIHGLCNC HNNXBMFYSA N InChi: